[Objective] The lithologic mechanism of Pisha sandstone erosion, and the mechanism and technique of anti-erosion and vegetation-promoting, and the corresponding application effects were analyzed systematically. The scientific problems and key technique needed further research were proposed to provide support for the comprehensive control of Pisha sandstone area.[Methods] On the basis of revealing the lithologic mechanism of Pisha sandstone erosion, a novel material of anti-erosion and vegetation-promoting, which is suitable for the application in ecological restoration in Pisha sandstone, was developed by the method of polymerization modification. The novel material was applied in a demonstration. Moreover, the problems and key techniques that needed to be studied further were proposed and discussed.[Results] Some of the chemical compositions were detected active and released when Pisha sandstone met water, which was the main reason for Pisha sandstone being eroded easily. A novel material of anti-erosion and vegetation-promoting was developed by the method of coating-polymerization modification. The novel material could form a consolidation layer on the surface with monomer-modified Pisha sandstone particles through physical-chemical action. The layer had the functions of hydrophobic water-holding, anti-swelling and growth promotion. The novel material behaved well in the performances of mechanical strength and resistances to UV degradation, freezing and thawing, and hydrolysis, and it would not cause pollution to the soil and water wherein.[Conclusion] Runoff and sediment yield on the slope could be reduced 70% and 90% respectively in the control area where was treated by the technique of anti-erosion and vegetation-promoting, as compared with those of the contrast area. And the vegetation coverage in a small demonstrated watershed increased from 25% to 75%, through which, the integration of anti-erodibility and growth promotion was achieved. The technique might provide a new approach for soil and water conservation and ecological restoration in Pisha sandstone area.