[Objective] From the perspective of water footprint, the coupling mechanism between agricultural economic growth and utilization of agricultural water resources in Pingtang County of Guizhou Province was analyzed in order to provide reference materials for ecological management of karst peak cluster depression.[Methods] Using the CROPWAT 8.0 software recommended by the Food and Agriculture Organization of the United Nations, to calculate the agricultural water footprint of Pingtang County, and using decoupling theory to analyse the decoupling situation between agricultural development and utilization of agricultural water resources in Pingtang County from 2001 to 2015.[Results] ① The water footprint and GDP of Pingtang County from 2002 to 2015 fluctuated and increased, but its growth rate was volatile. ② From the perspective of tapioelasticity index, the relationship between agricultural economic growth and agricultural water consumption is still unstable at the present stage, unsustainable utilization of agricultural water resources still exists; ③ The ideal or optimistic year for decoupling was 2007, followed by 2008. The worst coordination was 2006 year, and the trend of decoupling showed a trend of inverted "U" shape as a whole from 2002 to 2015; ④ In terms of area, the specific gravity range of weak decoupling area during the study period was 0%~97.9%(the largest was 2010, the second largest was 2013, and the smallest was 2011), the specific gravity range of strong decoupling area was 0%~100%(the largest was 2007, the second largest was 2008, and the smallest was 2010), and recession decoupling area specific gravity range was 0%~49.7% (it was 49.7% in 2011, and other years was 0).[Conclusion] Overall, agricultural economic growth and agricultural water use coordination is not good in Pingtang County.