[Objective] The purpose of this paper is to provide decision support for the regulation of sandy wasteland and the protection of ecological environment, and to provide new ideas and methods for the prevention and control of desertification and economic development in China.[Methods] Taking Weihe River and Luohe River as a research area, based on the necessity of remediation of local deserted land, sand land regulation status quo and the expected target, based on the advantages of sand land regulation in the research area, studying the development and application of sand and wasteland remediation model with ecological security as the core, the comprehensive benefit evaluation model of sand wasteland remediation based on entropy weight matter-element method is established. Based on this, the comprehensive benefit evaluation index in accordance with the research area was obtained and evaluated in order to promote the benign utilization of sandy land resources.[Results] The comprehensive benefits of sand remediation in the study area are excellent, and the remediation effect has reached the expected target.[Conclusion] The relevant countermeasures and safeguard measures for the remediation, development and utilization of sandy land under the new situation were put forward, thus promoting the virtuous utilization of sandy resources in the study area.