[Objective] The countermeasures for soil salinization control based on the comprehensive utilization of regional resources and management of soil and water resources were discussed in order to develop a new strategy for the management of soil and water resources and provide support for agricultural sustainable development, ecological protection and environmental management in semiarid and arid areas. [Methods] We reviewed the details on the measurements of salt-affected soils worldwide, and summed up the research experiences based on the field investigation in arid areas suffering from soil salinization in Northwest China. A new strategy was proposed by integrated analyzing the main issues existing in saline-alkali treatments. [Results] The main approach of the new developed strategy has two steps: to separate the salts from soil firstly, and then to desalt the salted drainage for irrigation, that would improve the efficiency of soil salinization control measures. It can be abbreviated as "double desalinization approach (DDA)" of soil salinization control measures. The strategy of DDA of soil salinization control measures can be summarized as "reducing regional water loss, leaching of soil salts with less water, intensive desalination of salted soil, and efficient utilization of soil and water resources". Among them, reducing regional water loss is the premise of water resource management and ecological protection in arid area. Leaching of soil salts with less water is the basis to reduce the cost of salt leaching time and water resources. Intensive desalination of salted soil is the key technology to separate the salts and water for reusing. And efficient utilization of water and soil resources is the core economic principle of agricultural development in semiarid and arid areas. [Conclusion] The new strategy of DDA of soil salinization control measures can increase the efficiency of desalination of soil and water by intensive management of soil and water resources in the arid areas. The risks relating to regional natural resources, environment and ecology of this strategy are relatively lower than the traditional methods, and the benefits of management could last for a longer time. The strategy can maintain and improve the regional economic development and the ecological services of ecosystem.