[Objective] The landscape change of Mu Us sandy land in the past 100 years was analyzed in order to provide basis for the study of ecological management in this area.[Methods] Through satellite image interpretation and field investigation, we found out the shooting site of four photos taken by Robert Sterling Clark expedition in the Mu Us sandy land in 1908, and rephotographed the photos of the past hundred years in 2019, and then compared the changes of ecological factors in the new and old photos.[Results] More than one hundred years ago, Mu Us sandy land was sparsely covered with vegetation, and the sandstorm was rampant. After the founding of the People's Republic of China, the local government organized the masses to carry out sand remediation. After decades of treatments, mobile sand dunes were fixed, regional vegetation was effectively restored, and soil erosion was effectively controlled.[Conclusion] Due to the fragile ecology of Mu Us sandy land, there is still the risk of desertification in the sand land that has been treated. It is necessary to integrate the treatment of Mu Us sandy land into the overall plan for ecological protection and high-quality development of the Yellow River basin, so as to make overall coordination and comprehensive treatment.