[Objective] The geomorphic differentiation characteristics of land use change in rocky desertification areas was explored, and the spatial-temporal change of land use under different geomorphologic conditions was investigated, in order to provide references for the rational use of land in rocky desertification areas.[Methods] Taking Guanling-Zhenfeng Huajiang rocky desertification comprehensive demonstration zone, Guizhou Province as a case study, the land use data, rocky desertification data, and geomorphic data in three periods of 2005, 2010, and 2013 were collected. The topographic distribution index and the comprehensive index of land use degree were derived by using GIS and RS technology, to study the geomorphic changes of the land use change.[Results] ① From 2005 to 2013, the area of grassland, construction land, forest land, unused land and water area in the karst areas was increased, while the area of cultivated land and garden land was decreased. The area of rocky desertification was decreased and the degree of rocky desertification was gradually reduced. ② Under different geomorphologic conditions, each land use type had its own dominant distribution area, the geomorphic differentiation of each land use type was basically stable. ③ The geomorphic differentiation of land use degree tended to be stable. From 2005 to 2013, the degree of land use showed as follows:erosion platform > peak-cluster depression > hill peak plateau > V-shape valley > dissolution-erosion of steep slope. ④ In terms of the distribution of different rocky desertification levels in different land types under the same geomorphologic conditions, rocky desertification mainly occurred in cultivated land, forest land, garden land and unused land, according to the distribution of rocky desertified land types in erosion platform, peak-cluster depression, hill-peak platform, V-shape valley, and dissolution-erosion of steep slope. There was no rocky desertification in the water area. From 2005 to 2013, rocky desertification in different geomorphologic conditions of the land type generally showed good transformation.[Conclusion] Each land use type has its dominant geomorphic area. Under different geomorphologic conditions, the distribution of rocky desertification vary in different land use types, mainly occurred in cultivated land, forest land, garden land and unused land.