[Objective] Taking Xinzhou City of Shanxi Province as an example, the pre-warning of ecological security in energy-ecological recombination region was discussed, in order to provide a basis for regional ecological protection planning and high-quality development.[Methods] Based on the pressure-state-response conceptual model framework, 21 indexes were selected from population, resources, economy, environment and ecological elements to establish the ecological security early warning and evaluation index system in energy-ecological recombination region. Entropy method was used to determine the weights and analyze the ecological security pre-warning in Xinzhou City from 2000 to 2018.[Results] ① In 2018, the comprehensive pre-warning values of 14 counties in Xinzhou City ranged from 0.356 2 to 0.587 0, with the average value of 0.491 2. The pre-warning level was within the range of medium to light, among which Xinfu District, Dingxiang County, Wutai County, Fanshi County and Jingle County were in the state of medium pre-warning level. The remaining seven counties were in the state of light pre-warning level. The overall ecological security of Xinzhou City was not optimistic because of its low ecological security level. ② From 2000 to 2018, the ecological security pre-warning values of Xinzhou City showed a slow upward trend. The number of counties with medium and light alarm level decreased, while the number of counties with light alarm level increased.[Conclusion] The ecological security in the research area presented unbalanced in space. The overall warning situation tended to be improved due to the decreasing pressure on economy, resources and environment in the system.