[Objective] Hazard and zoning of the Guangmingding landslide at the engineering site of the 500 m aperture spherical radio telescope (FAST) in Pingtang County, Guizhou Province were studied in order to provide a reference basis for the monitoring and prevention of landslide disaster at the FAST site and similar areas. [Methods] Topography & geomorphy, lithology & rock formation, geological structure, human engineering activities and disaster history were selected as the first-level assessment indexes, and based on this, the second-level assessment indexes were developed. Based on fuzzy analytic hierarchy process (FAHP), the research on hazard assessment of kast single landslide was carried out, assessment index system was built and the matrices of layers were completely operated by GIS technology. [Results] Most of Guangmingding slope was at generally medium and low hazard levels while some local area was at high hazard level. The high hazard areas were mainly located near the 1 H feed tower and three support columns in the fault fracture zone, and the high hazard areas accounted for about 4% of the study area. [Conclusion] The Guangmingding slope had potential safety problem, which is a threaten to operation of precision radio telescope facilities. The results are basically consistent with the actual situation, the method is innovative and operable in the hazard assessment of single landslide.