[Objective] The vulnerability and influencing factors of the social-economic-ecological system at tourism destinations in the Beijing-Tianjin-Hebei ecological conservation area were analyzed in order to provide a scientific support for reducing vulnerability and achieving sustainable development of the tourism destinations in the area. [Methods] Based on the social, economic and ecological subsystems, a comprehensive evaluation system of the vulnerability of tourism destinations in Beijing-Tianjin-Hebei ecological conservation area was constructed. Linear weighting method, natural breakpoint method and obstacle degree model were introduced to analyze the vulnerability and influencing factors of 23 county-level unit tourism destinations in Beijing-Tianjin-Hebei ecological conservation area in 2017. [Results] The average value of the comprehensive vulnerability index of the study area was 0.271 0, showing a mild vulnerability state. The distribution of social vulnerability, economic vulnerability and ecological vulnerability index of each study unit had obvious spatial differences, and was spatially concentrated. The grain output per unit area, urban-rural income gap ratio, industrial structure diversification index, per capita disposable income, and rural employees were the main factors influencing the vulnerability of tourism destinations in conservation areas. [Conclusion] At present, the overall sustainable development capacity of the study area is relatively good. Through the effective identification of factors influencing its vulnerability, countermeasures and suggestions, including grasping development opportunities, narrowing the gap between urban and rural areas, optimizing industrial structure and strengthening regional linkages, should be considered.