[Objective] The coupling and coordination between high-quality development and sustainable land resource utilization in Guangxi Zhuang Autonomous Region was explored in order to provide new ideas and case study references for regional coordinated development. [Methods] The spatial and temporal patterns of coordinated development between high-quality development and sustainable land resource utilization from 2009 to 2018 in Guanxi were quantitatively analyzed by using the entropy weight TOPSIS method, the coupling and coupling coordination degree model, and the spatial autocorrelation analysis method. [Results] ① The high quality development level of Guangxi maintained an upward trend. The sustainable utilization level of land resources fluctuated twice. The type of coordinated development roughly experienced four levels: reluctant coordination, primary coordination, intermediate coordination, and good coordination. ② The high quality development speed and the land resources sustainable use development rise rates were different in each city. The coordination degree of urban development gradually increased from west to east (inland to coastal). ③ During the study period, coordinated development among the 14 cities in Guangxi was not strongly influenced by region, and no city was greatly affected by the neighboring cities. [Conclusion] Over time, high quality development and sustainable land resource utilization level in Guangxi were improved, and the coupling coordination degree was not changed significantly. Across the region, the development speed of each city was not the same. The degree of spatial agglomeration or dispersion of coupling coordination degree was not obvious.