[Objective] The coupling and coordination status of various elements of the life community of regional mountains, water, forests, fields, and lakes were analyzed in order to carry out more accurate land space planning, ecological restoration, and comprehensive monitoring of natural resources. [Methods] An evaluation framework was constructed based on the indexes of comprehensive evaluation, coordination degree, coupling degree, and correlation index. Based on the PSR model, the evaluation index system was constructed from the five aspects of “mountain, water, forest, field, and lake”. The comprehensive evaluation model, the coupled coordination model, and the grey correlation model were used to explore the spatio-temporal differentiation characteristics and driving factors of the coupled coordination of the life communities in mountains, water, forests, fields, and lakes in Guangxi Zhuang Autonomous Region from 2005 to 2017. [Results] ① The comprehensive evaluation index of the life community of mountains, water, fields, and lakes rose from 0.918 in 2005 to 0.931 in 2017. Specific performance followed the order of water system > field system > forest system > lake system > mountain system. ② The coupling coordination degree of mountain, water, forest, field, and lake life communities decreased from 0.909 in 2005 to 0.861 in 2017. Although the coupling coordination status was considered good, it had experienced a downward trend. The highest combination coordination between two elements occurred for “water-field”. The highest combination coordination among three elements occurred for “water-forest-field”. The highest combination coordination among four elements occurred for “water-forest-field-lake”. ③ The main driving factor affecting the coupled and coordinated development of the life community in mountains, water, fields, and lakes was water, and the gray correlation degree was 0.723. The specific index factor was soil erosion control. [Conclusion] The life community of mountains, water, forest, field, and lake is an open conceptual category of “mountains, water, forest, field, and lake+”. According to the typical nature of each element, a coupling superposition recombination can be carried out, among which the water element is central to the coupling correlation of each element of the life community of mountains, water, forests, fields, and lakes, and soil erosion control is the key factor. Although the comprehensive level of the life community of mountains, water, forests, fields, and lakes in Guangxi has been improved, the coupling coordination is not likely to be good. Soil and water loss control should be taken as the starting point, and all elements of mountains, water, forests, fields, and lakes should be connected to carry out overall planning and ecological renovation. Integrated monitoring and a quality management system of natural resources needs to be developed in order to improve the state of coupling coordination and to realize sustainable, high quality development.