[Objective] The evolution characteristics of social-ecological-production landscape resilience in areas along the mainstream of the Yellow River in He'nan Province from 2000 to 2018 was quantitatively determined in order to guide the coordinated development of social life, ecological resources, the environment, and agricultural production activities in this region.[Methods] We constructed the social-ecological-productional landscape resilience (SEPLR) assessment framework to quantitatively study the evolution characteristics of the social-ecological-productional landscape resilience in He'nan Province along the mainstream of the Yellow River from 2000 to 2018. An ordered weighted average method was used to set up scenario preferences and to draw a map of resilience prediction under the guidance of various policies.[Results] ① Based on the overall characteristics, the SEPLR value of the areas along the mainstream of the Yellow River in He'nan Province from 2000 to 2018 varied from 0.47 to 0.52, presenting an upward trend. The spatial differences between cities kept expanding gradually. ② From the perspective of evolution characteristics, social system resilience and ecosystem resilience increased slowly, fluctuating between 0.14~0.65 and 0.08~0.30, respectively, and the production system resilience slightly fluctuated between 0.12~0.31. In terms of space, SEPLR and its subsystems overall presented a distribution pattern of "being strong in the center and weak on both sides", and the hierarchical structure was concentrated.[Conclusion] For cities along the Yellow River in He'nan Province, the resilience of "ecology first" was the highest of the four policy scenarios of "maintaining the status quo" "ecology first" "development first" and "agriculture first". In the future, the high-quality development of the Yellow River basin should be guided by the"ecology-first" policy.