[Objective] The trend and influencing factors of ecological security in the Three Gorges Reservoir area were studied in order to provide a scientific basis for promoting the development of ecological security in this area.[Methods] Based on pressure-status-response (PSR) model, an ecological security index system was established, and the ecological security status during 2015-2019 was evaluated by the entropy method and the analytic hierarchy process. According to data from the Three Gorges Reservoir area during 2015-2019, the dynamic changes of ecological security in this area were revealed by quantitative evaluation, and verification was performed using the grey clustering method.[Results] ① From 2015 to 2019, the correlation degree of ecological security in the reservoir area was greater than 0.7 for factors such as the application amount of pesticides per unit land area, the amount of topsoil loss caused by vegetation reduction, the ecological service index, and the environmental protection investment ratio. ② From 2015 to 2019, the comprehensive evaluation index of ecological security in some areas of the reservoir area showed an upward trend, while the comprehensive evaluation index of some areas decreased slightly. ③ The agglomeration characteristics of the PSR index in the Three Gorges Reservoir area did not change significantly with time. The high-high agglomeration area was mainly concentrated in the main urban area, which was in line with the general law of economic development. The low-low agglomeration areas were mainly concentrated in Yiling, Zigui, and other counties in the marginal areas. The low-high and high-low agglomeration areas were mainly distributed in the counties surrounding the low-low and high-high agglomeration areas.[Conclusion] The ecological security of the Three Gorges Reservoir area was significantly affected by some indicators. Ecological security construction of the Three Gorges Reservoir area should be promoted based on the important impact factors, and there are great differences between the districts and counties in the Three Gorges Reservoir area. Giving full attention and consideration to the leading role of some districts and counties is the key to the construction of an ecological security system in the Three Gorges Reservoir area.