[Objective] The ecological security of oasis land in Yili River valley was studied from the perspective of ecological civilization, and the main factors influencing the ecological security of land in this area were analyzed, in order to promote the construction of ecological civilization. [Methods] The PSR-entropy weight TOPSIS model was used to evaluate the ecological safety of oasis land in the Yili River valley from 2000 to 2018. The study results were used to establish a barrier factor diagnosis model to determine the ecological safety of oasis land in Yili River valley. [Results] ① Overall, the ecological safety of oasis land in the Yili River valley showed a slow upward trend with a slight increase. The ecological security level of land was grade Ⅲ, and the ecological security of land was in a general state, during which there have been fluctuations and changes, with a small decline in some years. ② The land ecological security situation in the standard layer changed significantly. In general, the situation concerning the ecological safety of soil in the pressure layer decreased, and the land ecological security at state and response levels showed an overall upward trend. ③ The barrier degree of land ecological pressure level showed an increasing trend, and resistance to the improvement of land ecological security level gradually increased. The main barrier factors included per capita forest and grass area, population density, per capita cultivated land area, application amounts of agricultural chemical fertilizer, and other indicators. [Conclusion] Overall, ecological security of oasis land in the Yili River valley showed a good trend, but the main obstacle factors have had a bad impact on improvement speed. Corresponding countermeasures should be taken to promote sustainable utilization of oasis land in the Yili River basin.