[Objective] In order to understand the effects of soil physicochemical properties and enzyme activities on slopes under different restoration measures after highway project disturbance in alpine wetland, we aim to provide theoretical reference basis for the screening of vegetation restoration model in alpine wetland, the management of soil erosion and the improvement of ecological environment. [Method] The three treatment slopes of natural succession, spraying grass planting and turf mulching and the original undisturbed control vegetation were taken as the research objects, and the soil physicochemical indexes and soil enzyme activities were measured to analyze their interrelationships and influencing factors. [Result] 1) All three restoration measures resulted in a significant increase (P<0.05) in soil pH and total potassium, and a significant decrease (P<0.05) in soil organic matter, total nitrogen, total phosphorus, and fine root biomass compared to the control; effective phosphorus increased and quick-acting potassium decreased compared to the control; the proportion of clayey silt particles in soil particles of the natural succession was not significantly different from the control, and the proportion of clayey silt particles in soil particles was significantly lower (P<0.05) in the spraying of grasses and turf mulch treatment; the turf mulch richness index did not differ significantly from the control, and the proportion of clayey silt particles in soil particles was significantly lower (P<0.05) under spraying of grasses and natural succession. The proportion of sticky powder particles in soil particles in the natural succession was not significantly different from that of the control, and the proportion of sticky powder particles in soil particles in the spraying and sodding treatments was significantly lower (P<0.05); the richness indices of sodding were not significantly different from that of the control, and those of spraying and sodding were significantly lower than that of the control (P<0.05), and the soil pH, organic matter, total nitrogen, quick-acting potassium, fine root biomass, and their richness indices in the sodding and sodding treatments were higher than those in the natural succession (P<0.05).2) Sprayed grass and turf replanting restored the four soil enzymes better than natural succession, and even catalase activity was restored to near control levels. 3)The correlation between the four enzyme activities and soil physicochemical properties was significant, and the urease activity was the most sensitive to soil physicochemical properties, which was able to evaluate the soil fertility of plateau wetland slope well. [Conclusion] Compared with natural succession, spraying grass and turf can effectively improve soil physicochemical properties and soil enzyme activity, and soil enzyme can be used as a sensitive indicator for evaluating soil fertility on slopes in plateau wetlands.