[Objective] The characteristics of the spatial dynamics of wind erosion at Wuwei City, Gansu Province and the controlled area of wind erosion and its prevention countermeasures were determined in order to provide scientific references for implementing measures to prevent wind erosion, conserve soil and water, and use ecological environmental construction practices in the city.[Methods] Multi-source geographic information data, applied remote sensing, a geographic information system (ArcGIS), and other technical means were used with the revised wind erosion equation (RWEQ) to calculate the five-period wind erosion modulus of Wuwei City from 2000 to 2020 to obtain the distribution of the regional wind erosion area, change characteristics, etc. These results were combined with a superposition analysis of spatial elements (such as the distribution of key construction projects) to put forward the principles of the city's wind erosion manageable area delineation and to apply them to delineate the manageable area of wind erosion at Wuwei City.[Results] RWEQ was able to estimate the multi-year wind erosion modulus at Wuwei City[5 788.98 t/(km²·yr)], with a multi-year average soil wind erosion of 1.92×10⁸ t. The model exhibited an overall decreasing and occasionally increasing trend over time, and the wind erosion intensity level was obviously weakened. Wind erosion intensity exhibited obvious spatial heterogeneity that was mainly located in Minqin County, Liangzhou District, and Gulang County. According to the multi-element superimposed wind erosion zoning management program, Wuwei City can manage a total of 2 872.66 km² of wind erosion area, of which 1 468.48 km² was at Minqin County, 708.75 km² was at Liangzhou District, and 695.43 km² was at Gulang County.[Conclusion] Wind erosion sub-area management should be the focus of wind erosion prevention and soil and water conservation in Wuwei City. According to the results of the wind erosion sub-area management division, for different administrative divisions, the flat Gobi desert area with low slope in the northern part of Minqin County is the key area of regional concern. Management measures should be based on the prevention of wind and sand erosion and the restoration of vegetation cover, and attention should be given to controlling the impact of man-made engineering and construction disturbances to make clear the scope of the regional management. Liangzhou District should focus on using a combination of engineering measures and biological measures, combined with governmental management. Gulang County should focus on closure measures and protecting natural vegetation. At the same time, special attention in the Gobi desert area should be given to the implementation of wind and sand erosion prevention and ecological restoration measures for construction activities such as large-scale photovoltaic power plants.