The historical process and significance of the study on water pollution's loss are analyzed briefly. Based upon the present situation analyses of the Weihe river water pollution, the water resource wealth loss of Weihe river basin is calculated and discussed by using the model of water resources wealth loss caused by water pollution,which is set up by means of Fuzzy- Grey method. The co nclusion shows that the Water resource Weath loss of water basin caused by pollution is serious.